FVIII Immunodepleted Deficient Human Plasma with VWF
Frozen
Packaging options
| 6-FDPFVIII-VWF | Bottle | 1 x 100 mL |
| 6-FDPFVIII-VWF-50 | Bottle | 1 x 50 mL |
| 6-FDPFVIII-VWF-500 | Bottle | 1 x 500 mL |
Human plasma immunodepleted of Factor VIII with a normal level of Factor von Willebrand (VWF), used for the search for inhibitors of Factor VIII. Frozen and poor in platelets.
Description of the FVIII Immunodepleted Deficient Human Plasma with VWF
Human FVIII deficient plasma is produced from a pool of human normal citrated plasma, immunodepleted to obtain a deficiency in factor VIII with VIII levels (antigen and activity) <1% while VWF levels (antigen and activity) are >50%.
Advantages
- No bovine additives
- No reconstitution error
- No plasma alteration linked to freeze-drying
Informations
Factor VIII is a glycoprotein with a molecular weight of 250,000 Da synthesized mainly by the liver.
It circulates in the plasma in the form bound to VWF which protects it from rapid proteolytic degradation.
It is activated by FXa or thrombin in FVIIIa which will complex with FIXa in the presence of phospholipids to activate FX in FXa. A patient who is deficient in FVIII has hemophilia A.
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