INHIBITORS

Description


Detection and determination of proteinases, studies on their interactions with substrates and effectors and the investigation of their physiological role are greatly facilitated by the use of proteinase inhibitors.
In this context, especially synthetic, low-molecular weight inhibitors of different selectivity are very useful. They are widely applied during purification and characterization of proteinases.
Furthermore, synthetic inhibitors are useful tools for suppression of undesired proteolytic activity. Depending upon the manner in which the inhibitor is attached to the enzyme, one distinguishes reversible and irreversible inhibitors.

Characteristics


Pentapharm offers a selection of inhibitors derived from benzamidine. They can help in the characterization of trypsin-like enzymes.
Most Pefablocs® exhibit a selective inhibitory activity on certain trypsin-like proteinases of physiological relevance. However, each inhibitor will of course display a characteristic action on other serine proteinases (see table on Ki-values page 47).

Advantages


Supplied lyophilized or frozen
Expiry date > 1 year
Glass vial or plastic tubes
Discount according to quantities

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