Factor XIa Control
| 5-1188 | Vial | 10 x 4.0 mL |
Purified preparation of Factor XIa for the ROX FXIa kit, titrated against the WHO international standard.
Description of the Factor XIa Control
Quality control plasma for the determination of FXIa in hemostasis.
Method / Application
The FIXa formed activates FX to FXa in the presence of FVIII, thrombin, phospholipids and calcium ions. The amount of FXa generated is determined by the hydrolysis of a chromogenic substrate of FXa.
The amount of para-nitroaniline released during this hydrolysis and measured at 405 nm is proportional to the concentration of FIXa in the reaction medium.
Informations
Factor XI (FXI) is a protein synthesized by the liver. It participates in the contact phase which initiates the intrinsic coagulation pathway.
It is activated by FXIIa to factor FXIa which will itself activate FIX in the presence of calcium ions.
