» Pefakit® APC-R Factor V Leiden

HEMOSTASIS COAGULATION ROUTINE THROMBOPHILIA FACTOR V LEIDEN / APCR

Pefakit® APC-R Factor V Leiden

Pefakit® APC-R Factor V Leiden is a functional coagulation test for the determination of resistance to activated protein C (APC-R) caused by the Factor V Leiden mutation.

Test based on an FV-dependent prothrombin activator, isolated from snake venom.

Reference	8-502-01
Presentation	Kit
Format	3 x 2.0 mL
Number of assays	3 x 40
Quote

Price list, safety data sheets and notices are accessible to our registered customers.

Reference	Presentation	Format	Number of assays	Quote	Product sheet
8-502-01	Kit	3 x 2.0 mL	3 x 40

Price list, safety data sheets and notices are accessible to our registered customers.

Resistance to activated protein C is an anomaly described by Dahlbäck in 1993. Bertina discovered in 1994 the presence of a mutation in the factor V (FV) gene. This mutation leads to the replacement at position 506 of an arginine by a glutamine (Arg506Gln), which affects one of the sites of cleavage of FV by PCa. As a result, FV "resists" inactivation by PCa. The mutated FV is referred to as FV Leiden. This factor V loses its function as a cofactor of the protein C system, that is to say of a system which inhibits coagulation; on the other hand, it retains its procoagulant properties. There are other cases of mutations related to the resistance of activated protein C.

Pefakit® APC-R Factor V Leiden is a functional plasma coagulation test which differs from other functional tests for resistance to APC by acting specifically at the prothrombinase complex level.

Any interference from UFH, LMWH or pentasaccharide in the blood sample is excluded by the addition of polybrene (heparin inhibitor) to reagents 1 and 2. The strength and specificity of the test are enhanced by the elimination of possible disturbances by factors upstream of the coagulation cascade and calcium independence. Results available on different types of analyzers.

Pefakit® APC-R Factor V Leiden Controls

	These kits are manufactured in accordance with the 98/79 EC directive for in vitro diagnostic devices. Only CE marked products can be used for diagnostic applications in Europe.
	These kits are intended for in vitro diagnostic use.
	These kits are for research use only and are not intended to be used for diagnostic procedures.
	Federal Drug Administration, FDA validates diagnostic kits for in vitro diagnostic use in the United States.
	Biological risk products.
	Storage between 2 and 8 ° C.
	Reactive in liquid form.
	Reactive in lyophilized form.
	Reactive in frozen form.
	Stability after opening at 2-8 ° C.
	Products that can be refrozen.
	Stability 12 months after refreezing at -20 ° C.
	Manufacturer.
	Importer
	Distributor.

HEMOSTASIS COAGULATION ROUTINE THROMBOPHILIA FACTOR V LEIDEN / APCR

Pefakit® APC-R Factor V Leiden

Price list, safety data sheets and notices are accessible to our registered customers.

Price list, safety data sheets and notices are accessible to our registered customers.

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Product sheet Pefakit® APC-R Factor V Leiden

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HEMOSTASIS COAGULATION ROUTINE THROMBOPHILIA FACTOR V LEIDEN / APCR

Pefakit® APC-R Factor V Leiden

Product sheet

Price list, safety data sheets and notices are accessible to our registered customers.

Price list, safety data sheets and notices are accessible to our registered customers.