Human Factor Xa – blocked active site (EGRck)
| 9-HCXA-EGR | Vial | 100 µg |
| 9-HCXA-EGR-1 | Vial | 1 mg |
Structure: 2 PM subunits: 16 200 and 28 800 Da, N-terminal Gla domain and 2 EGF domains.
Formulation : 20 mM HEPES, 150 mM NaCl, pH 7.4
Description of the Human Factor Xa – blocked active site (EGRck)
< 1 % Fxa activity - Active-site blocked
MW(Da) : 46 000
Extinction coef. : 11.6
Activity determined by coagulation and chromogenic tests.
Advantages
The vast majority of enzymes is pure (without additives) with > 95% purity SDS-PAGE.
Expiration date of one year from delivery.
Delivery in large quantities.
Discount according to quantities.
Informations
An enzyme is a protein that catalyzes a biochemical reaction. It converts a substrate into a product.
Each enzyme has a structure adapted to its function and its activity is dependent on an optimum temperature and pH. Factor X (FX) is a glycoprotein synthesized by the liver, dependent on vitamin K.
FX is involved in the common pathway of coagulation.
It is activated in FXa by the FT-FVIIa complex or by the FVIIIa-FIXa complex in the presence of phospholipids.
FXa is neutralized by TFPI and antithrombin.
EGRck : Glu-Gly-Arg chloromethyl ketone.
