Factor VIII is a glycoprotein with a molecular weight of 250,000 Da synthesized mainly by the liver.
It circulates in the plasma in the form bound to VWF which protects it from rapid proteolytic degradation.
It is activated by FXa or thrombin in FVIIIa which will complex with FIXa in the presence of phospholipids to activate FX in FXa. A patient who is deficient in FVIII has hemophilia A.
CRYOcheck™ Factor VIII Deficient Plasma with VWF is an immunounfolded plasma of FVIII that contains normal concentrations of von Willebrand factor (VWF).
FVIII has been validated as having less than 1% of the normal levels of antigen and activity, while the levels of antigen and activity of VWF are > 50%.
CRYOcheck™ Factor VIII Deficient Plasma with VWF aims to identify FVIII deficiency and support the management of hemophilia A in people aged 2 years and older.
Intended for in vitro diagnostic use.
- Ready to use after thawing, saves time.
- Convenient frozen format
- Ready to use quickly and without reconstitution errors.
- Protocol available on request.
The importance of VWF antigen levels in the performance of FVIII-deficient plasmas was demonstrated in a poster presented at ISTH 2021.
- 25 cryotubes x 1 mL or 1.5 mL of frozen plasma