Fibrinogen Reagent Kit

For this routine hemostasis test, the clotting time of the diluted citrated plasma is determined in the presence of excess thrombin (≈ 80 IU / mL) and a reaction accelerator.

Fibrinogen (Factor I) is a plasma soluble glycoprotein that is synthesized by the liver at a size of 340 kDa and circulating at a concentration of 2.6 to 3 mg/mL.
Fibrinogen is a dimer bound by disulfide bridges composed of 3 pairs of polypeptide chains not identical. Under the action of thrombin, fibrinogen is converted into fibrin. In combination with FXIII, calcium ions, fibrin forms a stable network that ensures coagulation.