DOAC-Stop™

DOAC-Stop™ is an innovative diagnostic test designed to simplify your diagnostics by eliminating interference from direct oral anticoagulants (DOACs). It allows you to perform thrombophilia testing, lupus anticoagulant (LA) assays, and factor measurements on plasmas containing DOACs.

This product effectively removes all types of DOACs (dabigatran, rivaroxaban, apixaban, edoxaban, betrixaban, and argatroban) without affecting plasma coagulation proteins. In less than 10 minutes, it absorbs up to 2,000 ng/ml of DOAC and leaves no residual effect.

It therefore enables you to verify the presence of DOACs in your samples and avoid false-positive results, particularly in lupus anticoagulant tests. The treated plasmas can then be used for factor assays and thrombotic risk testing.

A mini-tablet of DOAC-Stop in 1 ml of normal plasma to which 500 mg/ml of dabigatran, edoxaban, betrixaban, rivaroxaban, or apixaban has been added removes more than 95% of the DOAC within 5 minutes. There is no effect on the baseline aPTT for up to 3 hours of incubation following treatment.

The therapeutic use of DOACs is increasing. DOACs are known to interfere, to varying degrees, with practically all coagulation tests, and sometimes patients who require a coagulation test due to underlying issues are found to be taking DOACs. Specific antidotes for individual DOACs are being developed for therapeutic purposes, but they are not widely available for laboratory use.