Human Factor XI
| 9-HCXI-0150 | Vial | 50 µg |
| 9-HCXI-0150-1 | Vial | 1 mg |
Structure: homodimer comprising 2 subunits of 80 kDa linked together by disulfide bridges.
The monomers contain 4 repeated amino acid regions in tandem which they share with plasma prekallikrein.
Origin : Human Blood / Plasma
Description of the Human Factor XI
MW(Da): 160 000
Extinction coef.: 13.4
Formaulation : 50 % Glycerol / H₂O (v/v)
Advantages
The vast majority of zymogens is pure (without additives) with > 95 % purity SDS-PAGE.
No additive or preservative.
Informations
A proenzyme or zymogen is a protein precursor of an enzyme which can give, after activation, an active enzyme. Factor XI (FXI) is a protein synthesized by the liver.
It participates in the contact phase which initiates the intrinsic pathway of coagulation.
It is activated by FXIIa to factor FXIa which will itself activate FIX in the presence of calcium ions.
