Product derived from the venom of Crotalus durissus terrificus in freeze-dried form.
MW(Da) : 84 000
Convulxin (CVX), a potent platelet aggregation protein belonging to the C-type heterodimeric lectin family, is isolated from the venom of the snake Crotalus durissus terrificus. Neither antibodies against GPIb nor against echicetin had any effect on convulxin-induced platelet aggregation, demonstrating that, unlike other venom C-type lectins acting on platelets, GPIb is not not involved in convulxin-induced platelet activation.
Convulxin activates mammalian platelets via binding to the platelet collagen receptor p62/GPVI and clustering of glycoprotein VI (GPVI) receptors under physiological conditions.
GPVI occupancy and clustering activates Src family kinases, phosphorylating the Fc receptor γ chain and activating p72SYK which is critical for downstream activation of platelets.
Allows the study of platelet receptors.
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