Aprotinin concentrated solution 1M KIU
| 8-073-70 | Vial | 50 mL |
Aprotinin is a polyvalent reversible inhibitor of serine proteinases. Aprotinin is a polypeptide of 58 amino acids. Its active center is formed by 4 lysine groups, the tertiary structure shows a pearshaped unit which fits exactly into the binding site of serine proteinases.
Description of the Aprotinin concentrated solution 1M KIU
Therapeutic Application:
In a finished dosage form, Aprotinin is used to reduce perioperative blood loss and transfusion requirements in patients at high risk of major blood loss during and following cardiopulmonary bypass (CPB) in the course of coronary artery bypass graft surgery. The effects of aprotinin use in CPB involves a reduction in inflammatory response, through its inhibition of multiple mediators (e.g., kallikrein, plasmin), which translates into a decreased need for allogeneic blood transfusions, reduced bleeding, and decreased mediastinal re-exploration for bleeding.
Activity: Aprotinin solution (~200’000 KIU/ ml)
Storage:
May be used by the expiry date given on the label when stored unopened, protected from moisture, in the dark, 2 -8°C. Avoid contamination of the product by microorganisms. Shipment of product does not require cooling during the time of transportation.
Category: Research use only
Type: Protein
Advantages
Glass bottle or cryotube packaging. All the references benefit from decreasing price according to the quantities ordered.
Informations
Aprotinin is a versatile reversible inhibitor of protease serines (trypsin, plasmin, u-PA, chymotrypsin, kallikreine, elastase...). Aprotinin is used in chromogenic assays for the determination of antithrombin, heparin, α2-macroglobulin, FXa and thrombin to inhibit the unwanted activities of kallikrein or plasmin.
