DAPA

MW(Da) : 539 Extinction coef. : 4010 Potent and specific synthetic thrombin inhibitor. (Ki=10-7M). Bound to thrombin, le fluorescence intensity increase 3 fold.

Supplied lyophilized or frozen. Expiry date > 1 year. Glass vial or plastic tubes. Discount according to quantities.

Detection and determination of proteinases, studies on their interactions with substrates and effectors and the investigation of their physiological role are greatly facilitated by the use of proteinase inhibitors. In this context, especially synthetic, low-molecular weight inhibitors of different selectivity are very useful. They are widely applied during purification and characterization of proteinases. Furthermore, synthetic inhibitors are useful tools for suppression of undesired proteolytic activity. Depending upon the manner in which the inhibitor is attached to the enzyme, one distinguishes reversible and irreversible inhibitors.