The pNAPEP® line of chromogenic peptide substrates is a line of high quality substrates, which allow testing of serine proteinases. Their focus is on enzymes involved in coagulation and fibrinolysis for thrombin, Factor Xa, Factor XIIa, kallikrein, activated protein C, plasmin and plasminogen-SK. Our chromogenic substrates pNAPEP are equivalent to the brand name CHROMOGENIX, WERFEN, PENTAPHARM DSM or DIAGNOSTICA STAGO. For example, there are chromogenic substrates S-2238, S-2765, S-2732, S-2403, S-2444, S-2366, S-2251, S-2288, S-2403, S-2302, Pefachrom TH, Pefachrom VIIa, Pefachrom IXa and CBS 3139. These are synthetic peptides that react with proteolytic enzymes under formation of colour which can be followed spectrophotometrically and the intensity of which is proportional to the proteolytic activity of the enzyme. Typically, such chromogenic substrates are composed of 3 to 5 natural or artificial amino acids. They may be N-terminally protected to reduce undesired degradation by aminopeptidases. On their C-termini they are modified so that upon cleavage of the amide bond a chromogenic group is released. Most commonly used groups are the p-nitroaniline (pNA) which absorbs light of the wavelength of 405 nm.
Package Inserts, certificate of analysis supplied. Material safety Data Sheet (MSDS) supplied. Prolonged stability following reconstitution (> 3 months). We can supply milligram to gram. Discount according to quantities.
