Hereditary thrombophilia is a genetic cause of venous thromboembolism.
It is based on genetic mutations and polymorphisms.

THROMBO inCode Kit Universal is an allele specific test based on 6 simultaneous real-time PCR reactions. Each reaction analyses 2 loci (4 variants) using 4 allele specific Taqman® probes labelled with
different fluorophores: locus 1 (FAM/HEX) and locus 2 (TxR/Atto647N). For each locus, one probe is specific of the major allele and the other one is specific of the minor allele.
Each of the six AmpliMixes used to genotype a sample are dispensed in a 1,5 mL vial.
Measured fluorescence signals in each reaction tube are interpreted according to the calculations specified in section 10.3 in order to determine the genotypes of clinical samples.
The application programme of THROMBO inCode Kit facilitates the calculation of genotypes and generation of individualized reports per sample using the fluorescence data obtained.

Specificity > 99% Sensitivity > 99%
Thrombo inCode automatically integrates in a single tool :
- A panel of 12 genetic variants predisposing to a thrombotic event
- An algorithm that calculates a risk score for thrombosis on clinical and genetic data
- A summary of individualized recommendations. Lifespan 9 months.
Test time: 2h30
Protocol validated on CFX 96 / DX platforms from BIO-RAD with CFX MANAGER software, ABI7500 from Life Technologies with ABI7500 software and LightCycler® 480 II from ROCHE with LightCycler® Software. (Specialized hemostasis)

- 6 bottles x Amplimix 1 to 6 ready to use
- 1 TIC positive control vial ready to use