HEMOSTASIS COAGULATION ROUTINE REAGENTS THROMBOPHILIA FACTOR V LEIDEN / APCR
APC Control Kit
Normal and heterozygous controls for the validation of the assay of resistance to protein C activated by the coagulant method in hemostasis.
The APC CONTROL KIT contains quality control plasmas from donors with either a normal wild-type pattern or the heterozygous Factor V Leiden mutation genotype (FV: Q506).
The genotype of each donor was checked and verified by PCR typing.
Informations
The mutated FV is referred to as FV Leiden. This mutation leads to the replacement at position 506 of an arginine by a glutamine (Arg506Gln), which affects one of the sites of cleavage of FV by PCa. As a result, FV "resists" inactivation by PCa.
This factor V loses its function as a cofactor of the protein C system, that is to say of a system which inhibits coagulation; on the other hand, it retains its procoagulant properties.
There are other cases of mutations related to the resistance of activated protein C.
Documentation
Download the product sheetPrice list, safety data sheets and notices are accessible to our registered customers.
Chronometric assay
References
| 4-5344512 | Kit | 2 x 1.0 mL |
