HEMOSTASIS COAGULATION RESEARCH REAGENTS PLASMA DERIVED PROTEINS PLATELET FACTOR -4
Human platelet Factor-4
Formulation : 25 mM HEPES, 2 M NaCl, pH 7.4
MW(Da) : 29 000
Extinction coef. : 2.6
Determination of activity: neutralization with heparin
Isoelectric point: 7.6
Structure: homotetramer (approx. 7800 da)
Informations
Platelet factor 4 (PF4) is a peptide monomer of 70 amino acids (MW 7800 Da). PF4 is released from activated platelet alpha granules in a tetrameric form complexed with platelet proteoglycan. On release, the half-life of PF4 is very short, less than 5 minutes, because it quickly binds to glycosaminoglycans in the endothelial cells where it is stored. PF4 possesses potent anti-heparin activity by binding to it, forming a stochiometric complex, where 1 mg of PF4 will inhibit 27 IU of heparin.
Documentation
Download the product sheetPrice list, safety data sheets and notices are accessible to our registered customers.
References
9-HPF4-0180 | Vial | 100 µg |
9-HPF4-0180-1 | Vial | 1 mg |