Plasma with high level of C protein: > 150 %

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Protein C is a 62 kDa glycoprotein, synthesized by the liver in the presence of vitamin K. CP is at the center of a physiological system that inhibits coagulation: the anticoagulant system of protein C. Thrombin associated with thrombomodulin loses its procoagulant properties at the same time as it activates PC to active protein C (PCa). PCa in the presence of protein S, calcium and phospholipids is capable of cleaving FVa and FVIIIa blocking the amplification loop of thrombin generation.