The mutated FV is referred to as FV Leiden. This mutation leads to the replacement at position 506 of an arginine by a glutamine (Arg506Gln), which affects one of the sites of cleavage of FV by PCa. As a result, FV "resists" inactivation by PCa. This factor V loses its function as a cofactor of the protein C system, that is to say of a system which inhibits coagulation; on the other hand, it retains its procoagulant properties. There are other cases of mutations related to the resistance of activated protein C.
The controls are intended for use in conjunction with the Pefakit® APC-R Factor V Leiden (REF 502-01), a functional plasma test to determine resistance to activated protein C caused by the Factor V Leiden mutation (FV: Q506) or equivalent APC stress test.
Results available on different types of analyzers.
- 3 vials of human plasma for negative control.
- 3 flasks of human plasmas for heterozygous control.
