A complex web of biochemical and physical reactions between platelets and clotting factors at the site of vascular injury is required to achieve hemostasis.
Under flow conditions, platelet activation and coagulation processes are dynamically intertwined with each other affected by platelets, coagulation factors and their various inhibitors and activators.
CTI works to inhibit the intrinsic signaling pathway (contact pathway) of coagulation by reversibly binding to FXIIa.
Calcium ions are used to recalcify citrated blood, suppressing the inhibition of several coagulation factors (FIXa, FXa) allowing the extrinsic pathway to initiate its own activation.
