Factor VIII is a glycoprotein mainly synthesized by the liver. It circulates in the plasma in the form bound to VWF which protects it from rapid proteolytic degradation.
It is activated by FXa or thrombin in FVIIIa which will complex with FIXa in the presence of phospholipids to activate FX in FXa. A patient who is deficient in FVIII has hemophilia A.
CRYOcheck ™ Factor Deficient Plasma consist of pools of citrated human normal plasmas which have been depleted into a coagulation factor by immunoadsorption, buffered with HEPES buffer, aliquoted and frozen rapidly.
- Certificate of analysis supplied with each batch.
- Expiration date of 3 years from the date of manufacture with storage between -40 °C and -80 °C
- The other factors have been tested and the results are provided on the Certificate of Analysis that accompanies each lot number.
- Contains no inhibitor, suitable for research of inhibitors (Bethesda or Nijmegen)
- It is deficient both for antigenic assay and functional in hemostasis.
- CE adaptation on many analyzers on the market
- Technical validation file
- Reserved lots
- Precise rates indicated in the certificate of analysis for all factors
- Ready to use
- 25 cryotubes x 1 mL or 1.5 mL of frozen plasma
