Factor XII is a glycoprotein synthesized by the liver, zymogen of a serine protease. Its plasma half-life is 50 to 70 hours. This factor participates in the contact phase which initiates the intrinsic pathway of coagulation.
Activated on contact with a negatively charged surface, it becomes capable of activating prekallikrein to kallikrein, then FXI to FXIa in the presence of KHPM.
It is also able to activate plasminogen into plasmin.
- Undiluted citrated human plasma
- Ready to use after 3 min at 37°C
- Plasma from donors with congenital deficiency.
- Certificate of analysis mentioning the value of the measured parameter on request
- 25 cryotubes x 0.5 mL of frozen plasma