Fibronectin is a glycoprotein that exists in soluble form in plasma or in fibrillar form in the extracellular matrix. This protein modulates the interactions between cells and the extracellular matrix.
In the absence of fibrinogen, fibronectin controls cogulation.
Fibronectin can bind to fibrin to strengthen clots and make them more stable. Fibronectin has shown roles in platelet function, fibrinolysis, chemotaxis, phagocytosis, and opsonization.
In certain pathologies such as trauma, sepsis, liver disorders, the fibronectin level may be low. Conversely, some cancers can have high fibronectin levels.
The test is based on the quantification of fibronectin using 2 anti-FN monoclonal antibodies.
The first to bind fibronectin and the second coupled to peroxidase for detection. (Specialized hemostasis)
- Stability 2 months after opening.
- Reaction time 120 minutes.
- Sensitivity of the assay ranging from 0 to 2 µg / mL of fibronectin.
- 12 strips of 8 wells coated with anti-FN monoclonal antibody
- 2 adhesives for ELISA plate
- 1 vial x anti-FN monoclonal antibody coupled to peroxidase (POX)
- 1 vial x TMB chromogenic substrate (12 mL)
- 1 bottle x stop solution (15 mL)
- 3 vials x 2.5x concentrated dilution buffer (20 mL)
- 1 vial x Wash Buffer Concentrate 12.5 x (20 mL)
- 1 vial x lyophilized calibrator plasma