Fibrinogen is a soluble protein made by the liver. Under the action of thrombin, fibrinogen is converted into fibrin. In association with FXIII, calcium ions, fibrin forms a stable network which ensures coagulation.
All proteins are accompanied by certificates of analysis which describe the appropriate storage conditions. In order for us to guarantee the stability of the product, it is imperative that the storage conditions are observed. Brief centrifugation of the zymogens in their original packaging will fully recover the sample at the bottom of the tube. Never allow protein solutions to stay at room temperature for excessive periods of time. High temperatures can increase the rate of protein degradation. Avoid storing or maintaining diluted protein samples for an extended period of time. In general, purified proteins are inherently more stable in concentrated form. Many proteins are "clingy" by nature. To avoid protein loss due to adsorption, extremely diluted protein samples should be prepared in buffers containing excipients such as bovine serum albumin, polyethylene glycol, Prionex or gelatin.
