Tissue plasminogen activator (t-PA) is a protein involved in breaking down the blood clot. It is a serine protease found in the endothelial cells that line the blood vessels.
Like any enzyme, it converts plasminogen into plasmin, the main blood clot lysis enzyme.
Due to its lysis activity, t-PA is used in clinical medicine to treat cerebral embolism and thrombosis.
Its use is contraindicated in cases of cerebral hemorrhage or head trauma.
Antibodies lyophilized from a solution of 1 mg/mL in PBS buffer at pH 7.4 containing 0.02% sodium azide and 20 mg/mL mannitol.
After reconstitution the antibodies should be aliquoted and stored at -20°C.
Avoid repeated freezing and thawing cycles.