Phospholipids constitute a catalytic surface for the enzymatic activation of coagulation factors. Lupus circulating anticoagulants are heterogeneous autoantibodies of the IgG and IgM type directly directed against a variety of anionic phospholipids such as cardiolipin, phosphatidylserine or phosphatidylinositol or against proteins having the capacity to bind to phospholipids such as β2-glycoprotein I (β2 -GPI).
The contribution of phospholipids (PL) does not modify the levels of factors VIII, IX, XI, XII on normal plasmas without deficit nor LA.
The contribution of PL does not modify the levels of factors VIII, IX, XI, XII on the known deficient plasmas with and without LA (isolated constitutional or acquired deficiency) The supply of PL leads to an increase in factors VIII, IX, XI, XII in plasmas with LA.
DOPE : DOPS : DOPC = 5 : 3 : 2
Optimal blend of phospholipids for coagulation. (DOPE = di-oleyl phosphatidyl ethanolamine).