» TECHNOCHROM® Protein C

HEMOSTASIS COAGULATION ROUTINE THROMBOPHILIA PROTEIN C

TECHNOCHROM® Protein C

Colorimetric assay

Quantitative determination of functional protein C in citrated human plasma by chromogenic method in hemostasis.

The TECHNOCHROM® Protein C kit allows functional colorimetric assay of plasma protein C (PC) by amidolytic method, according to a principle of specific activation of PC by a snake venom (Agkistrodon contortrix): PROTAC®. The protein C thus activated hydrolyzes a chromogenic substrate.
The quantity of para-nitroaniline released during this hydrolysis is measured at 405 nm and is proportional to the concentration of protein C present in the reaction medium.

Access on the manufacturer's website TECHNOCLONE

Reference	4-5341013
Presentation	Kit
Number of assays	30 à 60
Quote

Price list, safety data sheets and notices are accessible to our registered customers.

Reference	Presentation	Number of assays	Quote	Product sheet
4-5341013	Kit	30 à 60

Price list, safety data sheets and notices are accessible to our registered customers.

Protein C (PC) is a vitamin K dependent plasma protein that regulates coagulation by inhibiting FVa and FVIIIa and helps limit the extension of the thrombus.
Numerous clinical studies have shown that a PC deficiency (acquired or congenital) is a risk factor for venous thrombosis. PC is a 62 kDa glycoprotein, synthesized by the liver in the presence of vitamin K.
PC circulates in plasma in an inactive form at a concentration of approximately 4 μg / ml.
Thrombin bound to thrombomodulin loses its procoagulant properties and activates PC into activated PC PCa in the presence of its cofactor, protein S, of calcium and phospholipids, is capable of inactivating activated FV and activated FVIII, true catalysts of coagulation, thus blocking the amplification loop of thrombin generation and limiting extension of the thrombus.

- Technical validation file
- Linearity: 0 - 130 (activity%)
- End point or kinetic method on hemostasis analyzer
- Detection limit: < 1% (activity%) kinetic or end point method
- Stability of reagents on analyzers for 3 days

- 3 vials x 1 mL of Protac®
- 3 vials x 1 mL of PCa-2 substrate
- 1 vial x 1 mL PC 1 (125%)
- 1 vial x 1 mL PC 2 (75%)
- 1 vial x 1 mL PC 3 (25%)
- 1 Protein C buffer (60mL)

	These kits are manufactured in accordance with the 98/79 EC directive for in vitro diagnostic devices. Only CE marked products can be used for diagnostic applications in Europe.
	These kits are intended for in vitro diagnostic use.
	These kits are for research use only and are not intended to be used for diagnostic procedures.
	Federal Drug Administration, FDA validates diagnostic kits for in vitro diagnostic use in the United States.
	Biological risk products.
	Storage between 2 and 8 ° C.
	Reactive in liquid form.
	Reactive in lyophilized form.
	Reactive in frozen form.
	Stability after opening at 2-8 ° C.
	Products that can be refrozen.
	Stability 12 months after refreezing at -20 ° C.
	Manufacturer.
	Importer
	Distributor.

HEMOSTASIS COAGULATION ROUTINE THROMBOPHILIA PROTEIN C