Lupus anticoagulants (LA) are heterogeneous autoantibodies of the IgG and IgM type directly directed against a variety of anionic phospholipids such as cardiolipin, phosphatidylserine or phosphatidylinositol or against proteins having the capacity to bind to phospholipids such as β2-glycoprotein I (β2-GPI).
The presence of LA is primarily detected using sensitive in vitro assays using phospholipids, such as TCA ( Activated cephalin) or dRVVT. They have the in vitro capacity to prolong phospholipid-dependent clotting times but are most often associated with thrombotic complications in vivo (venous or arterial thrombosis, thrombocytopenia and fetal losses) and do not predispose to a risk of bleeding.
DRVVT is routinely used in screening for LA. It is considered specific and robust.
Each batch is supplied with a certificate of analysis showing the following results :
- TCA (sensitive lupus)
- TCA (1 : 1 Pool mix)
- TCA on silica (SCT)
- Kaolin Clotting Time
- DRVVT report
- LA hexagonal phase
- PNP (platelet neutralization) IgG / IgA / IgM for :
º Anti-cardiolipin
º Anti-β-2-glycoprotein 1
º Anti-phosphatidylserine
Expiration date of 2 years from the date of manufacture with storage between -40 °C and -80 °C
- Easily adaptable, the reagent is designed for use on most hemostasis analyzers.
- Ready to use.
- 25 cryotubes x 0.5 mL or 1 mL of frozen plasma
