Vitronectin (Vn) is an adhesive glycoprotein, synthesized by the liver, released in plasma and present in the extracellular matrix. Vn binds PAI-1. This complex fully activates PAI-1, unlike PAI-1 in solution, where it does not appear to be stable and inactive. Vn therefore seems to regulate the enzymatic specificity of PAI-1, by stabilizing it. Decreased Vn levels occur in DICs and liver disease (cirrhosis). Vn deposition is associated with atherosclerotic lesions.
Antibody lyophilized from a solution of 0.5 mg / mL in 10 mM bicarbonate buffer pH 9.6. After reconstitution the antibodies should be aliquoted and stored at -20 ° C. Avoid repeated freezing and thawing cycles.
