Vitronectin (Vn) is an adhesive glycoprotein, synthesized by the liver, released in plasma and present in the extracellular matrix. Vn binds PAI-1. This complex fully activates PAI-1, unlike PAI-1 in solution, where it does not appear to be stable and inactive. Vn therefore seems to regulate the enzymatic specificity of PAI-1, by stabilizing it. Decreased Vn levels occur in DICs and liver disease (cirrhosis). Vn deposition is associated with atherosclerotic lesions.
Antibodies lyophilized from a solution of 1 mg/mL in PBS buffer at pH 7,4. After reconstitution the antibodies should be aliquoted and stored at -20°C. Avoid repeated freezing and thawing cycles.
