After activation by thrombin, the mature protein negatively regulates fibrinolysis by removing plasminogen binding sites to fibrin. TAFI (Thrombin Activatable Fibrinolysis Inhibitor) is a single chain glycoprotein synthesized by the liver and circulating at a plasma concentration of 50 nM. Thrombin cleaves the zymogen and releases the 92 amino acids activating peptide containing 4 N-glycosylation sites and the plamsinogen recognition site. TAFI plays an important role in the interaction between the fibrinolytic, anticoagulant and procoagulant systems.
Most inhibitors exhibit a selective inhibitory activity on certain trypsin-like proteinases of physiological relevance. However, each inhibitor will of course display a characteristic action on others serines proteinases.
Supplied lyophilized or frozen. Expiry date > 1 year. Glass vial or plastic tubes. Discount according to quantities.
