Factor VIII is a glycoprotein mainly synthesized by the liver. It circulates in the plasma in the form bound to VWF which protects it from rapid proteolytic degradation. It is activated by FXa or thrombin in FVIIIa which will complex with FIXa in the presence of phospholipids to activate FX in FXa. A patient who is deficient in FVIII has hemophilia A.
Lyophilized antibody to be reconstituted with 0.5mL of distilled water. Antibody also reacts with baboon and rabbit FVIII.
The lyophilized presentation allows greater stability until the expiration date.
