» APC Resistance Kit

HEMOSTASIS COAGULATION ROUTINE THROMBOPHILIA FACTOR V LEIDEN / APCR

APC Resistance Kit

Chronometric assay

Determination of resistance to protein C activated by the coagulant method.

The APC Resistance Kit is a functional plasma coagulation test that differs from other functional tests for resistance to APC by acting specifically at the prothrombinase complex.
It is based on an FV-dependent prothrombin activator isolated from snake venom.
The strength and specificity of the test are improved by eliminating possible disturbances by factors upstream of the coagulation cascade and calcium independence.

Access on the manufacturer's website TECHNOCLONE

Reference	4-5344510
Presentation	Kit
Number of assays	3 x 40
Quote

Price list, safety data sheets and notices are accessible to our registered customers.

Reference	Presentation	Number of assays	Quote	Product sheet
4-5344510	Kit	3 x 40

Price list, safety data sheets and notices are accessible to our registered customers.

Resistance to activated protein C is an anomaly described by Dahlbäck in 1993.
Bertina discovered in 1994 the presence of a mutation in the factor V (FV) gene.
This mutation leads to the replacement at position 506 of an arginine by a glutamine (Arg506Gln), which affects one of the sites of cleavage of FV by PCa. As a result, FV "resists" inactivation by PCa.
The mutated FV is referred to as FV Leiden. This factor V loses its function as a cofactor of the protein C system, that is to say of a system which inhibits coagulation; on the other hand, it retains its procoagulant properties. There are other cases of mutations related to the resistance of activated protein C.

- Designed for use on the majority of hemostasis analyzers.
- Minimum expiration date of 2 years after the date of manufacture.
- Specificity 100%
- Sensitivity 100%
- Clear discrimination between genotypes
- Specialized hemostasis

Not affected by :

- Lupus anticoagulants
- Protein C / protein S
- Antithrombin
- Fibrinogen and abnormal PT
- FVIII / FX / TFPI / D-Dimers
- Unfractionated heparins (UFH) and low molecular weight heparins up to 1.0 IU / mL

- Vials suitable for hemostasis analyzers
- Protocols are available on request
- Excellent stability on board hemostasis analyzers
- Excellent linearity over a large measurement area

- 3 vials x 2mL R1: RVV-V (+ APC), lyophilized
- 3 vials x 2mL R2: RVV-V (- APC), lyophilized
- 3 vials x 4mL R3: prothrombin activator, lyophilized
- 3 vials x 2mL R4: plasma diluent, lyophilized
- 1 vial x 1mL FV-L negative control
- 1 vial x 1mL FV-L heterozygous control

APC Control Kit

	These kits are manufactured in accordance with the 98/79 EC directive for in vitro diagnostic devices. Only CE marked products can be used for diagnostic applications in Europe.
	These kits are intended for in vitro diagnostic use.
	These kits are for research use only and are not intended to be used for diagnostic procedures.
	Federal Drug Administration, FDA validates diagnostic kits for in vitro diagnostic use in the United States.
	Biological risk products.
	Storage between 2 and 8 ° C.
	Reactive in liquid form.
	Reactive in lyophilized form.
	Reactive in frozen form.
	Stability after opening at 2-8 ° C.
	Products that can be refrozen.
	Stability 12 months after refreezing at -20 ° C.
	Manufacturer.
	Importer
	Distributor.

HEMOSTASIS COAGULATION ROUTINE THROMBOPHILIA FACTOR V LEIDEN / APCR