VON WILLEBRAND FACTOR
VWF ANTIGEN
ELISA ASSAY

TECHNOZYM® VWF:AG ELISA

Cat Num. ConditioningPackage size  
4-5450201kit12 x 8
ELISA kit for determination of von Willebrand Factor antigen in plasma and concentrates.
The von Willebrand Syndrome (vWS) is the most frequently occurring hemorrhagic disease; it may be hereditary as well as acquired, caused by quantitative or qualitative defects of the vWF. Determining the vWF antigen is an essential part of the diagnosis.The vWF: Ag ELISA allows a differential diagnosis between hemophilia A and vWS and additionnal diagnostics in case of hepatic and vascular diseases.

Kit contents:

  • 1 bottle of Washing buffer concentrate (80 mL)
  • 1 bottle of Incubation Buffer (90 mL)
  • 5 calibrators, lyophilized
  • 1 vial of control Low plasma, lyophilized
  • 1 vial of control High plasma, lyophilized
  • 1 vial of Conjugate polyclonal Anti-vWF-POX (0.3 mL)
  • 1 bottle of TMB (12 mL)
  • 12 ELISA strips (12 x 8 wells)
Use
  • Test time: 60 minutes.
  • Sensitivity: 0 - 1.4 U/mL vWF Ag.
Characteristics
The von Willebrand Factor (vWF) is a large, multifunctional glycoprotein, occupying a key position in primary haemostasis. It has a multiple structure with several functions:
  • It is the carrier protein for Factor VIII in plasma; it forms a complex and thus protects Factor VIII from early proteolytic decomposition.
  • It acts as a mediator for platelet aggregation by attaching itself to platelet membrane receptors (GP Ib and GP lIb/IIIa) following previous platelet activation.
  • It plays a part in primary haemostasis by acting as a mediator between adhesioned platelets and the subendothelium (lesioned vascular wall).
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