TECHNOZYM® FXIII-A SUB ELISA
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ELISA test used for determination of FXIII-A subunit in human plasma and in cell lysates.
Plasma FXIII is a heterotetramer (FXIII A2B2) consisting of two potentially active A Subunits (FXIII-A) and two carrier/inhibitory B Subunits (FXIII-B). All A subunits are complexed with B subunits in plasma, while about 50 % of the B subunits exist in free form. Free A-subunits only exist in the extremely rare inherited FXIII-B deficiency. Inherited deficiency of FXIII-A or autoantibody directed against FXIII-A causes severe bleeding diathesis with high risk of intracranial bleeding. In women who lack FXIII-A, pregnancy cannot be maintained.