ADAMTS-13
ADAMTS 13 INHIBITORS
ELISA ASSAY

TECHNOZYM® ADAMTS-13 INH

Cat Num. ConditioningPackage size  
4-5450401kit12 x 8
4-5450451kit6 x 8
Chromogenic ELISA for determination of human autoantibodies (IgG) against ADAMTS-13 for the diagnosis of thrombotic thrombocytopenic purpura (TTP).
The TECHNOZYM® ADAMTS-13 INH ELISA is a test for detection of human autoantibodies (IgG) in serum or plasma against ADAMTS-13, the protease which is responsible for cleaving unusually large vWF (UlvWF).

Kit contents:

  • 1 bottle of Wash Solution (80 mL)
  • 1 bottle of Incubation buffer (90 mL)
  • 5 calibrators, lyophylized (0.5 mL)
  • 1 vial of positive control, lyophilized (0.5 mL)
  • 1 vial of negative control, lyophilized (0.5 mL)
  • 1 vial of Conjugate (0.3 mL)
  • 1 bottle of TMB (12 mL)
  • 1 bottle of Stop Soliution (12 mL)
  • 12 ELISA test strips (12 x 8 wells)
  • 2 adhesive films
Use
  • Test time 210 minutes.
  • Sensitivity: 0.5 - 120 % (activity) and 0 - 1.5 mg/mL (antigen)
Characteristics
Most of anti-ADAMTS-13 autoantibodies inhibit ADAMTS-13 activity and thus non-cleaved ULvWF accumulates in plasma. This is believed to be the major cause for thrombotic thrombocytopenic purpura (TTP). TECHNOZYM® ADAMTS-13 INH test makes it possible to differentiate between congenital (gene polymorphisms) and acquired (autoantibodies) TTP when coupled to an activity assay and to control efficacy of plasma exchange therapy.

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