TECHNOCHROM® ATIII ANALYZER KIT
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Complete reagent kit suitable for the chromogenic determination of ATIII on auto-analyzers.
The TECHNOCHROM® AT III modular reagent is a system of reagents for the chromogenic determination optimized for the manual method (Reagent A1, Th 1 and Buffer A1) and different types of auto analyzers (Reagent A2 and Reagent Th-1). The optimised combination of the Substrate Th-1 with Reagents A1 or A2 respectively is mentioned in the application sheet for the auto analyser used, which is available on request.
- 1 vial of ATIII Reagent A2 (43 UI)
- 1 vial of Substrate AT III Th‑1 (10 μmol)
- 2 vials of Buffer A (25 mL) (+ Reagent A1)
Antithrombin is also termed Antithrombin III (AT III). The designations Antithrombin I through to Antithrombin IV originate in early studies carried out in the 1950s by Seegers, Johnson and Fell.
Antithrombin I (AT I) refers to the absorption of thrombin onto fibrin after thrombin has activated fibrinogen. Antithrombin II (AT II) refers to a cofactor in plasma, which together with heparin interferes with the interaction of thrombin and fibrinogen. Antithrombin III (AT III) refers to a substance in plasma that inactivates thrombin. Antithrombin IV (AT IV) refers to an antithrombin that becomes activated during and shortly after blood coagulation. Only AT III and possibly AT I are medically significant.