SYNTHETIC IRREVERSIBLE INHIBITORS

Cat Num.ProductMW(Da)FormulationSize
9-BEGRCK-06

Biotinylated EGR chloromethylketone

10 mM HCl1 mg
9-FEGRCK-06

Fluorescein-EGR-chloromethylketone

DMSO1 mg
9-BFPRCK-06

Biotinylated FPR-chloromethylketone

10 mM HCl1 mg
9-FFPRCK-06

Fluorescein-FPR-chloromethylketone

DMSO1 mg
9-FPRCK-01

FPR-chloromethylketone (PPACK)

669.5H-(D)-Phe-Phe-Arg-chloromethylketone5 mg
9-EGRCK-01

EGR-chloromethylketone (GGACK)

619.9H-Glu-Gly-Arg-chloromethylketone5 mg
8-399-01

Pefabloc® SC

Pefabloc® SC is an irreversible proteinase inhibitor with broad specificity for serine proteinases. It is suitable for biopharmaceutical downstream purification because of its superior solubility, stability, inhibitory activity and low toxicity.

239.74-(2-aminoethyl)-benzenesulfonylfluoride hydrochloride (AEBSF)1 g


Inhibition constants Ki in μM of Pefabloc inhibitors
for serine proteinases

Description


Detection and determination of proteinases, studies on their interactions with substrates and effectors and the investigation of their physiological role are greatly facilitated by the use of proteinase inhibitors.
In this context, especially synthetic, low-molecular weight inhibitors of different selectivity are very useful. They are widely applied during purification and characterization of proteinases.
Furthermore, synthetic inhibitors are useful tools for suppression of undesired proteolytic activity. Depending upon the manner in which the inhibitor is attached to the enzyme, one distinguishes reversible and irreversible inhibitors.

Characteristics


Pentapharm offers a selection of inhibitors derived from benzamidine. They can help in the characterization of trypsin-like enzymes.
Most Pefablocs® exhibit a selective inhibitory activity on certain trypsin-like proteinases of physiological relevance. However, each inhibitor will of course display a characteristic action on other serine proteinases (see table on Ki-values page 47).

Advantages


Supplied lyophilized or frozen
Expiry date > 1 year
Glass vial or plastic tubes
Discount according to quantities

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