NOTECHIS SCUTATUS VENOM

Cat Num.ProductMW(Da)ConservationtargetSize
8-117-01

Noscarin

54 0002° C / 8° CThe prothrombin activator present in the venom of the mainland tiger snake venom (Notechis scutatus) is capable of cleaving the Arg274-Thr275 and Arg323-Ile324 bonds of bovine prothrombin. Prethrombin and meizothrombin occur as intermediates during prothrombin activation. This venom activity on prothrombin is greatly stimulated by the presence of Ca2+, phospholipid and FVa.

Description


Snake venom proteases are useful tools for studying coagulation reactions.
Venoms contain more than 20 different compounds, mostly proteins and polypeptides.
Some of the proteins in snake venom have very specific effects on various biological functions including blood coagulation, blood pressure regulation, transmission of the nervous or muscular impulse and have been developed for use as diagnostic tools.
Plasma coagulation factors are usually inactive and require proteolytic activation as a first step towards a chronometric or colorimetric assay.
It is often advantageous to use specific enzymes from snake venoms to activate coagulation factors rather than physiological activators.
In contrast to other activators, many snake venom enzymes are not dependent from cofactors, phospholipid or calcium ions.

Characteristics


All of our venom products are supplied in 50 % glycerol / water for storage at -20° C or supplied lyophilized at 2-8° C.
Expiry date = 1 year

Advantages


The venom proteases offered are highly purified, homogenous preparations with the indicated activities.

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