FACTOR ASSAYS
FACTOR XIa
CHROMOGENIC ASSAY

FACTOR XIA CONTROL

Cat Num. Conditioning  
5-118810 x 4,0 mL
Factor XIa Control intended for use with the Rox Factor XIa kit.
Lyophilized preparations of human Factor XIa in packages of 10 vials. The Factor XIa Control is calibrated against the NIBSC reference reagent for Activated Blood Coagulation Factor XI (FXIa), 11/236, and potency assigned in Units/mL.
Characteristics
Factor XI (FXI) is a dimeric protein of 160 kDa, which is activated to FXIa by FXIIa or by thrombin. Activation of FXI may occur inadvertently during protein purifications and FXIa can be a contaminant in intermediate or final products. FXIa functional activity is determined in a chromogenic method. FXIa in the sample activates human FIX to FIXa in the presence of calcium ions. Generated FIXa activates human FX in the presence of human FVIII, calcium ions and phospholipid. The amount of activated FX is determined from the hydrolysis of a chromogenic FXa substrate and is related to the FXIa activity of the sample. The concentration of functionally active FXIa is assigned vs. a FXIa Calibrator and expressed in Units. Not intended for analysis of patient plasma.

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