ECHIS CARINATUS VENOM

Cat Num.ProductMW(Da)ConservationtargetSize
9-ECVII-2011

E. Carinatus II Protease

56 000-25° C / -15° CMetalendo-peptidase, single chain, Prothrombin activator, Cleavage of Arg323-Ile324 bond in prothrombin to form meizothrombin. Start at a 1:500 (enzyme: substrate) mass ratio for activation and adjust after results.100 µg
8-116-01

Ecarin

55 000 to 60 0002° C / 8° CDetermination of prothrombin levels in patients undergoing anticoagulant therapy (hirudin or thrombin inhibitors). Based on the interaction of hirudin with meizothrombin a simple ecarin clotting test for the monitoring of hirudin levels has been developed (Nowak and Bucha, 1993).50 EU
8-119-03

Echicetin

30 0002° C / 8° CEchicetin is a C-type lectin from Echis carinatus sochureki that binds to platelet glycoprotein Ibα and blocks von Willebrand factor and thrombin binding. It can be used either to block these GPIbα functions or, if labelled with 125I or biotin or fluorescein isothiocyanate, to measure GPIbα expression levels. In the presence of plasma, echicetin agglutinates platelets via GPIbα and IgM and can be used to assess GPIbα expression levels directly, independently of von Willebrand factor levels.

Description


Snake venom proteases are useful tools for studying coagulation reactions.
Venoms contain more than 20 different compounds, mostly proteins and polypeptides.
Some of the proteins in snake venom have very specific effects on various biological functions including blood coagulation, blood pressure regulation, transmission of the nervous or muscular impulse and have been developed for use as diagnostic tools.
Plasma coagulation factors are usually inactive and require proteolytic activation as a first step towards a chronometric or colorimetric assay.
It is often advantageous to use specific enzymes from snake venoms to activate coagulation factors rather than physiological activators.
In contrast to other activators, many snake venom enzymes are not dependent from cofactors, phospholipid or calcium ions.

Characteristics


All of our venom products are supplied in 50 % glycerol / water for storage at -20° C or supplied lyophilized at 2-8° C.
Expiry date = 1 year

Advantages


The venom proteases offered are highly purified, homogenous preparations with the indicated activities.

THEY TRUST US

OUR PARTNERS