CRYOCHECK™ LA SURE™
||Conditioning||Package size ||
|SUR-10||25 x 1,0 mL||300 ||
A dilute Russell’s Viper Venom Time (drVVT) reagent intended to confirm the presence of lupus anticoagulants (LA) in citrated human plasma.
LA are autoantibodies that are specifically directed against negatively charged phospholipids. They occur in various clinical conditions, especially autoimmune diseases. LA have traditionally been detected using phospholipid sensitive in vitro clotting tests. The drVVT showed improved sensitivity to LA over the APTT partially due to a reduced phospholipid concentration. Russell’s viper venom directly activates factor X, bypassing factor VII of the extrinsic pathway and the contact and antihemophilic factors of the intrinsic pathway.
Recent guidelines and recommendations for laboratory detection of lupus anticoagulants.
The International Society on Haemostasis and Thrombosis (ISTH) and the British Committee for Standards in Haematology (BCSH) have recently updated their lupus anticoagulant (LA) detection guidelines. The Clinical and Laboratory Standards Institute (CLSI) subsequently will publish its first LA guideline. General agreement exists on issues such as sample preparation, the use of dilute Russell viper venom time (dRVVT) in diagnostic repertoires, the use of normalized ratios, calculations to demonstrate phospholipid dependence, calculations to demonstrate inhibition, and interpretive reporting.