THROMBOPHILIA
PROTEIN S
CLOTTING ASSAY

CRYOCHECK™ CLOT S

Cat Num. ConditioningPackage size  
CCS-152 x 5 x 1,5 mL150
CCS-302 x 5 x 3,0 mL300
Clot-based assay intended for the quantitative determination of protein S activity in citrated human plasma.
cryocheck™ clot S initiates the common pathway of coagulation in plasma using a Russell’s viper venom (RVV-X) reagent to convert factor X to Xa in the presence of activated protein c (APc), bypassing all factors above the common pathway12. When mixed with protein S deficient plasma, samples from patients with a protein S deficiency or dysfunction will have shortened cryocheck clot S clotting times relative to samples with normal levels of functional protein S. The clotting time is proportional to the amount of functional protein S in the patient’s plasma and this can be quantified using a calibration curve.

Kit contents:

  • Protein S Deficient Plasma
  • Clot C Activator (+ C & S Diluent)
Features & Benefits
  • Frozen format eliminates reconstitution errors
  • Unaffected by factor VIII:C activity levels up to 600 %
  • Unaffected by samples from patients heterozygous for the factor V Leiden mutation
  • Interference by lupus anticoagulants has not been observed
  • Up to 300 tests per kit when using 3.0 mL format

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