THROMBOPHILIA
PROTEIN C
CLOTTING ASSAY

CRYOCHECK™ CLOT C

Cat Num. ConditioningPackage size  
CCC-152 x 5 x 1,5 mL150
CCC-302 x 5 x 3,0 mL300
Clot-based assay intended for the quantitative determination of protein C activity in citrated human plasma.
cryocheck™ Clot C functions by direct activation of protein C in the patient sample using Protein C Activator. The common pathway of coagulation is initiated with a Russell’s viper venom (RVV-X) reagent to convert factor X to Xa and bypassing all factors above the common pathway. Patients with a protein C deficiency or dysfunction will have shortened cryocheck Clot C clotting times relative to patients with normal levels of functional protein C. The clotting time is proportional to the amount of functional protein C in the patient’s plasma and this can be quantified using a calibration curve.

Kit contents:

  • Protein C Deficient Plasma
  • Clot C Activator (+ C & S Diluent)
Characteristics
  • Frozen format eliminates reconstitution errors
  • Unaffected by factor VIII:C activity levels up to 600 %
  • Unaffected by samples from patients heterozygous for the factor V Leiden mutation
  • Interference by lupus anticoagulants has not been observed
  • Up to 300 tests per kit when using 3.0 mL format

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