CROTALUS DURISSUS TERRIFICUS VENOM

Cat Num.ProductMW(Da)ConservationtargetSize
8-119-02

Convulxin

84 000-20° CConvulxin, a heterodimeric C-type lectin isolated from Crotalus durissus terrificus venom, activates mammalian platelets via binding and clustering of p62/GPVI-receptors under physiological conditions. Occupation and clustering of p62/GPVI may activate Src family kinases phosphorylating Fc receptor Ɣ-chain and activate p72syk that is critical for downstream activation of platelets. Convulxin may be used in studies on platelet receptors. 50 µg

Description


Snake venom proteases are useful tools for studying coagulation reactions.
Venoms contain more than 20 different compounds, mostly proteins and polypeptides.
Some of the proteins in snake venom have very specific effects on various biological functions including blood coagulation, blood pressure regulation, transmission of the nervous or muscular impulse and have been developed for use as diagnostic tools.
Plasma coagulation factors are usually inactive and require proteolytic activation as a first step towards a chronometric or colorimetric assay.
It is often advantageous to use specific enzymes from snake venoms to activate coagulation factors rather than physiological activators.
In contrast to other activators, many snake venom enzymes are not dependent from cofactors, phospholipid or calcium ions.

Characteristics


All of our venom products are supplied in 50 % glycerol / water for storage at -20° C or supplied lyophilized at 2-8° C.
Expiry date = 1 year

Advantages


The venom proteases offered are highly purified, homogenous preparations with the indicated activities.

THEY TRUST US

OUR PARTNERS