BOTHROPS ATROX VENOM

Cat Num.ProductMW(Da)ConservationtargetSize
8-101-04

Batroxobin

43 0002° C / 8° CDue to its specification on fibrinogen (cleaves alpha chain) and its ability to clot platelet-rich plasma without affecting the integrity and functions of platelets, and thanks to its insensitivity to thrombin inhibitors, batroxobin has found several applications as a tool in blood coagulation research and diagnosis.
Batroxobin can be used to determine fibrinogen in plasma, to measure the batroxobin clotting time (Reptilase® time) as a heparin-insensitive parallel to the thrombin time, to investigate dysfibrinogenemias, and to test the contractile system of platelets. Furthermore, batroxobin is used for defibrinogenation of plasma.
100 BU

Description


Snake venom proteases are useful tools for studying coagulation reactions.
Venoms contain more than 20 different compounds, mostly proteins and polypeptides.
Some of the proteins in snake venom have very specific effects on various biological functions including blood coagulation, blood pressure regulation, transmission of the nervous or muscular impulse and have been developed for use as diagnostic tools.
Plasma coagulation factors are usually inactive and require proteolytic activation as a first step towards a chronometric or colorimetric assay.
It is often advantageous to use specific enzymes from snake venoms to activate coagulation factors rather than physiological activators.
In contrast to other activators, many snake venom enzymes are not dependent from cofactors, phospholipid or calcium ions.

Characteristics


All of our venom products are supplied in 50 % glycerol / water for storage at -20° C or supplied lyophilized at 2-8° C.
Expiry date = 1 year

Advantages


The venom proteases offered are highly purified, homogenous preparations with the indicated activities.

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