AGKISTRODON CONTORTRIX VENOM
|36 000 to 42 000||2° C / 8° C||Protac®, a single chain glycoprotein, is a fast-acting protein C activator isolated from the venom of the copperhead snake Agkistrodon contortrix. It rapidly converts protein C of human and other vertebrates into activated protein C which may be determined either by measuring its prolonging effect on the activated partial thromboplastin time (APTT) or by measuring its enzyme activity by means of a specific chromogenic substrate. |
Protac is therefore used for the determination of protein C and protein S levels in plasma.
Snake venom proteases are useful tools for studying coagulation reactions.
Venoms contain more than 20 different compounds, mostly proteins and polypeptides.
Some of the proteins in snake venom have very specific effects on various biological functions including blood coagulation, blood pressure regulation, transmission of the nervous or muscular impulse and have been developed for use as diagnostic tools.
Plasma coagulation factors are usually inactive and require proteolytic activation as a first step towards a chronometric or colorimetric assay.
It is often advantageous to use specific enzymes from snake venoms to activate coagulation factors rather than physiological activators.
In contrast to other activators, many snake venom enzymes are not dependent from cofactors, phospholipid or calcium ions.
All of our venom products are supplied in 50 % glycerol / water for storage at -20° C or supplied lyophilized at 2-8° C.
Expiry date = 1 year
The venom proteases offered are highly purified, homogenous preparations with the indicated activities.