Protein S is a vitamin K dependent protein. It is a physiological inhibitor of coagulation.
It acts as a cofactor of activated protein C by promoting the inactivation of FVa and FVIIIa, prothrombin, of the prothrombinase complex, FX.
A protein S deficiency can be either acquired (hepatocellular insufficiency, vitamin K deficiency, anti-protein S antibody, ...) or constitutional (heterozygous or homozygous deficiency) grouped into 2 types depending on whether the deficiency is quantitative (type I) or qualitative (type II).
The CRYOcheck™Clot S™ set activates the common coagulation pathway by Russel viper venom (RVV-X) which activates factor X to factor Xa in the presence of activated protein C and thus eliminates the influence of other upstream factors of the common way. (Specialized hemostasis)
- Route of activation by RVV-X
- Linearity : 5 to 150%
- Stability 8 hours after opening
- Frozen presentation
- Compact, color-coded boxes for easier identification in freezers
- Expiration date of 2 years from the date of manufacture with storage between -40 °C and -80 °C
- Unaffected by high FVIII levels: 600%
- No interference with heparins: 1.2 IU / mL
- No additional dilutions
- No waste
- Suitable for large series
- No reconstitution
- Easy identification
- Vials suitable for hemostasis analyzers
Protein S deficient plasma :
- 5 vials x 3 or 1.5mL
Clot S ™ Activator :
- 5 vials x 3 or 1.5mL
