PC is a vitamin K dependent plasma glycoprotein.
In the presence of its cofactor, protein S, calcium and phospholipids, it exerts an anticoagulant activity by inactivating FVa and FVIIa.
It also promotes fibrinolysis (clot lysis) by inactivating PAI-1 - (plasminogen activator inhibitor -1)
It works by direct activation of protein C in the patient's plasma. Activation of the common pathway of coagulation is initiated by Russel viper venom (RVV-X) which activates factor X to factor Xa and thus eliminates the influence of other factors upstream of the common pathway. (Specialized hemostasis)
Patients with protein C deficiency or dysfunction will have a shorter clotting time.
The clotting time is proportional to the amount of PC in the patient's plasma.
- Route of activation by RVV-X by two venoms RVV-X and PROTAC®
- Linearity -> 5 to 150%
- Stability 8 hours after opening and refrozen
- Frozen presentation
- Compact, color-coded boxes for easier identification in freezers
- Expiration date : 2 years from the date of manufacture with storage between -40 °C and -80 °C
- Unaffected by high FVIII levels: 600%
- No interference with heparins: 1.2 IU / mL
- No additional dilutions
- No waste
- Suitable for large series
- No reconstitution
- Easy identification
- Vials suitable for hemostasis analyzers
Protein C Deficient Plasma :
- 5 vials x 3 or 1.5mL
Clot C Activator :
- 5 vials x 3 or 1.5mL
