LA are heterogeneous autoantibodies of IgG and IgM type directly directed against a variety of anionic phospholipids such as cardiolipin, phosphatidylserine or phosphatidylinositol or against proteins having the capacity to bind to phospholipids such as β2-glycoprotein I (β2-GPI ).
LA are characterized by their ability to prolong clotting time in in vitro tests such as lupus-specific TCA, Kaolin partial thromboplastin time, dRVVT, and diluted prothrombin time (dPT).
ACTICLOT dPT is a coagulation test which allows detection of LA in plasma. The screening test (LA Buffer + dPT ACtivator) allows the detection of LA in the patient's plasma if the clotting time is prolonged.
The confirmation test (LA Phospholipid + dpT activator) allows confirmation of LA in the patient's plasma if the clotting time is significantly shortened compared to the time obtained in the screening.
- Screening and confirmation tests can be performed at the same time or separately.
- Adaptable to analyzers.
- 3 vials x LA buffer (40 tests/vial)
- 3 vials x phospholipids
- 6 vials x dPT activator, lyophilized (40 tests/vial)
