These kits are manufactured in accordance with the 98/79 EC directive for in vitro diagnostic devices. Only CE marked products can be used for diagnostic applications in Europe.
These kits are intended for in vitro diagnostic use.
These kits are for research use only and are not intended to be used for diagnostic procedures.
Federal Drug Administration, FDA validates diagnostic kits for in vitro diagnostic use in the United States.
Biological risk products.
Storage between 2 and 8 ° C.
Reactive in liquid form.
Reactive in lyophilized form.
Reactive in frozen form.
Stability after opening at 2-8 ° C.
Products that can be refrozen.
Stability 12 months after refreezing at -20 ° C.
The IMUBIND® Tissue PAI-1 ELISA Kit is an enzyme immunoassay for the determination of human PAI-1 in tissue extracts and cell culture supernatants.
Number of assays
Price list, safety data sheets and notices are accessible to our registered customers.
Plasminogen activator inhibitor 1 (PAI-1) is a glycoprotein, the primary inhibitor of t-PA and u-PA. It plays an essential role in controlling any excessive activation of fibrinolysis. It is present in plasma associated with vitronectin, in free form or associated with t-PA and in the alpha granules of platelets.
Fibrinolysis corresponds to the solubilization of the fibrinous thrombus by plasmin, an enzyme originating from plasminogen adsorbed to fibrin. Plasminogen is activated by t-PA and u-Pa. PAI-1 by inhibiting plasminogen activators, it controls the degradation of fibrinous thrombus. A decrease in fibrinolytic activity promotes the occurrence of thrombosis, while excessive fibrinolysis leads to hemorrhages.
The test detects latent (inactive) and active forms of PAI-1 complexes and remains insensitive to PAI-2.
- 96 microwells coated with anti-human PAI-1 IgG
- 2 vials x biotinylated human anti-PAI-1 antibody, lyophilized
- 1 vial x substrate, TMB, 11 mL
- 1 bottle x detergent, 25% Triton X-100, 12 mL
- 2 sachets x PBS buffer, pH 7.4
- 1 vial x streptavidin-HRP, 60 μL
- 1 vial x lyophilized enzyme conjugate diluent
- 6 PAI-1 standard vials, lyophilized